Three Palestinian protesters were fatally shot in separate clashes in and around Jerusalem.
Three Israeli settlers were killed Friday in an alleged stabbing attack in the occupied West Bank, according to the Israeli military.
Security forces prohibited Palestinian men under the age of 50 from entering Jerusalem's Old City for Friday Muslim prayers this week, .
The Associated Press said including Friday's violence, "Palestinians have killed 47 Israelis, two visiting Americans and a British tourist in stabbings, shootings and car-ramming attacks against civilians and soldiers".
Muslims said they would not pray at the mosque until the metal detectors were removed.
Egypt is extremely anxious about the disproportionate use of force by police against Palestinians in Jerusalem and around Al-Aqsa Mosque, according to a statement.
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Thousands of Palestinians have marched towards Al-Aqsa in protest at the installation of the metal detectors, with Israeli forces using rubber bullets against some of the most violent demonstrators.
The mosque was reopened after a two-day closure, with Israel installing metal detectors at the mosque gates, which Palestinians say aim to change the status quo - a delicate balance of prayer and visiting rights.
A picture of the three Palestinians was later shared on the Facebook page of Fatah, the faction led by Palestinian Authority President Mahmoud Abbas, which described them as "martyrs" who "ascended to heaven for Jerusalem".
'Israel is committed to maintaining the status quo at the Temple Mount and the freedom of access to the holy places, ' the security cabinet said in a statement. The site is open for women of all ages and for men over the age of 50, a police spokesperson said.
Clashes between Israeli security forces and Palestinians broke out after the recent implementation of new Israeli security measures.
The unrest follows revelations on Thursday that Israel's Construction and Housing Ministry is planning a further expansion of settlements which could cut off East Jerusalem from the West Bank city of Ramallah.
